Wiktoria Giedroyć-Piasecka, M.Sc.

A3/314
+48 (71) 320 28 94
wiktoria.giedroyc-piasecka@pwr.wroc.pl

Research profile

Analysis of protein-ligand interactions focusing on the enzymes interaction with their small-molecule inhibitors.

 

Development and validation of theoretical models of inhibitor activity.


Publications

  1. W. Giedroyć-Piasecka, E. Dyguda-Kazimierowicz, W. Beker, M. Mor, A. Lodola, W. A. Sokalski, Physical Nature of Fatty Acid Amide Hydrolase Interactions with Its Inhibitors: Testing a Simple Nonempirical Scoring Model, J.Phys.Chem. B 118 (51), 14727-14736 (2014) DOI
  2. W. Giedroyć-Piasecka, M.Sc. Thesis: Theoretical analysis of protein-ligand interactions: prediction of the binding mode and binding affinity, (2012) [Bioinformatics, Chemistry Department of Wroclaw University of Technology, supervisor: dr inż. Edyta Dyguda-Kazimierowicz]

Conference presentations

Oral contributions:

 

„Inhibition models of fatty acid amide hydrolase: the problem of choice of amino acid residues to represent the enzyme active site"; Wiktoria Giedroyć-Piasecka, Edyta Dyguda-Kazimierowicz, W. Andrzej Sokalski; "Numbers-Computers-Life": 3rd Mathematics-Informatics-Bioinformatics Student Conference, 19-21 April 2013, Jagiellonian University, Kraków, Poland

 

„Structure-based development of small molecule inhibitors for acute leukemia";
Jolanta Grembecka, Dmitry Borkin, Aibin Shi, Shihan He, Trupta Purohit, Jonathan Pollock, Wiktoria Giedroyć-Piasecka, W. Andrzej Sokalski, Edyta Dyguda-Kazimierowicz, Tomasz Cierpicki; Modeling & Design of Molecular Materials 2012, 10-14 September 2012, Wrocław University of Technology, Wrocław, Poland

 

 

Posters:

 

 "Phosphotriesterase-catalyzed hydrolysis of organophosphorus pesticides: modeling of the enzyme-substrate complexes"; Edyta Dyguda-Kazimierowicz, Wiktoria Giedroyć-Piasecka, W. Andrzej Sokalski; 2nd symposium on "Protein Engineering for Biocatalysis", Greifswald University, 29-31 August 2012, Greifswald, Germany